Suffice it to say – it’s not a winning combination. There are two definitive hacks you’ll need to get things to work.
First, a plugin to disable canonical URL redirection. Second, a hack to wp-settings.php that circumvents the XO php configuration’s not having $_SERVER['REQUEST_URI'].
Update: the second hack will break the non-admin part of the site in the context of the current site I’ve been working on. So your mileage may vary.